Research
Glucotrim 24 mg
3% Corosolic Acid (equivalent to 72 mg standard potency)
The active ingredient in Glucotrim is corosolic acid.
Diabetes Res Clin Pract. 2006 Mar 18;
Effect Of Corosolic Acid On Postchallenge Plasma Glucose Levels.
Fukushima M, Matsuyama F, Ueda N, Egawa K, Takemoto J, Kajimoto Y, Yonaha N, Miura T, Kaneko T, Nishi Y,
Mitsui R, Fujita Y, Yamada Y, Seino Y.
Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan;
Health Informatics Research Group, Translational Research Informatics Center, Foundation for Biomedical
Research and Innovation, 1-5-4, Minatojima-minamimachi, Chuo-ku, Kobe, 650-0047, Japan.
Corosolic acid (CRA) is a substance extracted from Lagerstroemia speciosa L. and has been reported to have
biological activities in in vitro and experimental animal studies. In this study, 31 subjects were orally
administered 10mg CRA or a placebo, on different occasions, in a capsule 5min before the 75-g oral glucose
tolerance test (OGTT) in a double-blind and cross-over design. Nineteen subjects had diabetes, seven had
impaired glucose tolerance, one had impaired fasting glucose, and four had normal glucose tolerance
according to the 1998 WHO criteria. There were no significant differences in plasma glucose levels before
and 30min after the administration. CRA treatment subjects showed lower glucose levels from 60min until
120min and reached statistical significance at 90min. In this study, we have shown for the first time that
CRA has a lowering effect on postchallenge plasma glucose levels in vivo in humans.
PMID: 16549220 [PubMed - as supplied by publisher]
Biol Pharm Bull. 2006 Mar;29(3):585-7
Antidiabetic Effects Of Corosolic Acid In KK-Ay Diabetic Mice.
Miura T, Ueda N, Yamada K, Fukushima M, Ishida T, Kaneko T, Matsuyama F, Seino Y.
Department of Clinical Nutrition, Suzuka University of Medical Science, Mie, Japan. miura@suzuka-u.ac.jp
The antidiabetic effects of corosolic acid (CA) were investigated in KK-Ay mice, an animal model of type 2
diabetes. CA (2 mg/kg body weight) reduced the blood glucose levels of KK-Ay mice 4 h after a single oral
dose. CA (2 mg/kg) reduced the blood glucose levels in KK-Ay mice 2 weeks after a single oral dose and also
significantly lowered plasma insulin levels were in KK-Ay mice under similar conditions. CA-treated KK-Ay
mouse blood glucose significantly decreased in an insulin tolerance test. These results support the
hypothesis that CA improves glucose metabolism by reducing insulin resistance. Therefore CA may be useful
for the treatment of type 2 diabetes.
PMID: 16508174 [PubMed - in process]
J Ethnopharmacol. 2003 Jul;87(1):115-7.
Antidiabetic Activity Of A Standardized Extract (Glucosol) From Lagerstroemia Speciosa Leaves In Type II
Diabetics. A Dose-Dependence Study.
Judy WV, Hari SP, Stogsdill WW, Judy JS, Naguib YM, Passwater R.
SIBR, Inc., 4112 20th Street West, Bradenton, FL 34205, USA.
The antidiabetic activity of an extract from the leaves of Lagerstroemia speciosa standardized to 1%
corosolic acid (Glucosol) has been demonstrated in a randomized clinical trial involving Type II diabetics
(non-insulin-dependent diabetes mellitus, NIDDM). Subjects received a daily oral dose of Glucosol and blood glucose levels were measured. Glucosol at daily dosages of 32 and 48mg for 2 weeks showed a significant reduction in the blood glucose levels. Glucosol in a soft gel capsule formulation showed a 30% decrease in blood glucose levels compared to a 20% drop seen with dry-powder filled hard gelatin capsule formulation (P<0.001), suggesting that the soft gel formulation has a better bioavailability than a dry-powder formulation.
PMID: 12787964 [PubMed - indexed for MEDLINE]
